Higher carbohydrate intake can have more adverse effects on key atherogenic lipoproteins (eg, increase the apolipoprotein B-to-apolipoprotein A1 ratio) than can any natural fats….Robust data from observational studies support a harmful effect of refined, high glycaemic load carbohydrates on mortality.

Andrew Menta and Salim Yusuf, writing in The Lancet Public Health 2018.